Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV†
Identifieur interne : 000511 ( 2020/Analysis ); précédent : 000510; suivant : 000512Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV†
Auteurs : Jared S. Morse ; Tyler Lalonde ; Shiqing Xu ; Wenshe Ray LiuSource :
- Chembiochem [ 1439-4227 ] ; 2020.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (usage thérapeutique), Conception de médicament, Cysteine endopeptidases (), Cysteine endopeptidases (génétique), Cysteine endopeptidases (métabolisme), Humains, Infections à coronavirus (), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (transmission), Pneumopathie virale (), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (transmission), RNA replicase (), RNA replicase (génétique), RNA replicase (métabolisme).
- MESH :
- génétique : Cysteine endopeptidases, RNA replicase.
- métabolisme : Cysteine endopeptidases, RNA replicase.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Infections à coronavirus, Pneumopathie virale.
- Antiviraux, Conception de médicament, Cysteine endopeptidases, Humains, Infections à coronavirus, Pneumopathie virale, RNA replicase.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (therapeutic use), Betacoronavirus (enzymology), Betacoronavirus (genetics), Coronavirus Infections (drug therapy), Coronavirus Infections (prevention & control), Coronavirus Infections (transmission), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Cysteine Endopeptidases (metabolism), Drug Design, Humans, Pneumonia, Viral (drug therapy), Pneumonia, Viral (prevention & control), Pneumonia, Viral (transmission), RNA Replicase (chemistry), RNA Replicase (genetics), RNA Replicase (metabolism).
- MESH :
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases, RNA Replicase.
- chemical , genetics : Cysteine Endopeptidases, RNA Replicase.
- chemical , metabolism : Cysteine Endopeptidases, RNA Replicase.
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- enzymology : Betacoronavirus.
- genetics : Betacoronavirus.
- prevention & control : Coronavirus Infections, Pneumonia, Viral.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- Drug Design, Humans.
Abstract
With the current trajectory of the 2019‐nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. Although little is known about the virus, an examination of the genome sequence shows strong homology with its better‐studied cousin, SARS‐CoV. The spike protein used for host cell infection shows key nonsynonymous mutations that might hamper the efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. Other key drug targets, including RNA‐dependent RNA polymerase and coronavirus main proteinase (3CLpro), share a strikingly high (>95 %) homology to SARS‐CoV. Herein, we suggest four potential drug candidates (an ACE2‐based peptide, remdesivir, 3CLpro‐1 and a novel vinylsulfone protease inhibitor) that could be used to treat patients suffering with the 2019‐nCoV. We also summarize previous efforts into drugging these targets and hope to help in the development of broad‐spectrum anti‐coronaviral agents for future epidemics.
Url:
DOI: 10.1002/cbic.202000047
PubMed: 32022370
PubMed Central: 7162020
Affiliations:
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PMC:7162020Le document en format XML
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Although little is known about the virus, an examination of the genome sequence shows strong homology with its better‐studied cousin, SARS‐CoV. The spike protein used for host cell infection shows key nonsynonymous mutations that might hamper the efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. Other key drug targets, including RNA‐dependent RNA polymerase and coronavirus main proteinase (3CLpro), share a strikingly high (>95 %) homology to SARS‐CoV. Herein, we suggest four potential drug candidates (an ACE2‐based peptide, remdesivir, 3CLpro‐1 and a novel vinylsulfone protease inhibitor) that could be used to treat patients suffering with the 2019‐nCoV. 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Morse</name><name sortKey="Xu, Shiqing" sort="Xu, Shiqing" uniqKey="Xu S" first="Shiqing" last="Xu">Shiqing Xu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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